Why is it important?
Prescribing helicobacter eradication therapy is complex and usually requires the user to look up the eradication regime for the patient and then manually prescrib each drug, taking considerable time. This protocol streamlines and standardises that process to save time and ensure accurate prescribing.
What does it look like?
When triggered the following option is shown to the user (as long as they have not already prescribed eradication therapy on the same day:
The user is then asked whether or not it is First-Line treatment.
The next question will depend on any coded penicillin allergies or intolerances on the patient record.
- If the patient is not penicillin allergic the following options are shown:


- If the patient is penicillin allergic the following options are shown:


Clicking on any of the prescribing options will present pre-defined acute prescriptions to issue, ending with an acute prescription for Omeprazole 20mg for 7 days.
For patients already on a PPI, a prompt will offer the user to decide whether to continue prescribing omeprazole 20mg or take no action if it is determined that the existing PPI is sufficient for gastroprotection.
Eradication Therapy Combinations
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| Drug 1 | Drug 2 | Drug 3 | Drug 4 |
No penicillin allergy | 1st Line / 2nd Line | Amoxicillin 500mg 2bd | Clarithromycin 500mg bd | Omeprazole 20mg bd | n/a |
No penicillin allergy | 1st Line / 2nd Line | Amoxicillin 500mg 2bd | Metronidazole 400mg bd | Omeprazole 20mg bd | n/a |
No penicillin allergy | 2nd Line | Amoxicillin 500mg 2bd | Tetracycline 250mg 2qds | Omeprazole 20mg bd | n/a |
No penicillin allergy | 2nd Line | Amoxicillin 500mg 2bd | Levofloxacin 500mg od | Omeprazole 20mg bd | n/a
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h/o penicillin allergy | 1st Line | Clarithromycin 250mg bd | Metronidazole 400mg bd | Omeprazole 20mg bd |
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h/o penicillin allergy | 1st Line / 2nd Line | Bismuth subsalicylate 262.5mg 2qds | Tetracycline 250mg 2qds | Metronidazole 400mg bd | Omeprazole 20mg bd |
h/o penicillin allergy | 2nd Line | Levofloxacin 500mg od | Metronidazole 400mg bd | Omeprazole 20mg bd |
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How to get it
System Triggers
System trigger: Add a code
Run mode: Always run
Add codes: 168378007, 168271003, 89538001, 736696002, 513161000000105
Change management considerations
Your team need to be aware that this protocol will offer prescribing of eradication therapy when a positive helicobacter result is recorded.